Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097652 | 0.94 | PIK3CD (0.38) | PIK3CDPIK3CAMTORKDRPIK3CG | |
| SCHEMBL8091352 | 0.94 | PIK3CA (0.41) | PIK3CDPIK3CAMTORKDRPIK3CG | |
| SCHEMBL8082001 | 0.91 | PIK3CD (0.42) | PIK3CDPIK3CAMTORKDRPIK3CG | |
| SCHEMBL8093656 | 0.91 | PIK3CD (0.44) | PIK3CDPIK3CAMTORPIK3CGPIK3CB | |
| SCHEMBL8091240 | 0.90 | PIK3CA (0.39) | PIK3CDPIK3CAMTORKDRPIK3CG | |
| SCHEMBL8088889 | 0.88 | PIK3CD (0.44) | PIK3CDPIK3CAMTORKDRPIK3CG | |
| SCHEMBL8090864 | 0.87 | PIK3CD (0.47) | PIK3CDPIK3CAMTORPIK3CGPIK3CB | |
| SCHEMBL8083631 | 0.87 | PIK3CD (0.41) | PIK3CDPIK3CAMTORKDRPIK3CG | |
| SCHEMBL8099345 | 0.87 | PIK3CD (0.44) | PIK3CDPIK3CAMTORKDRPIK3CG | |
| SCHEMBL8096245 | 0.86 | PIK3CA (0.40) | PIK3CDPIK3CAMTORKDRPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |