SCHEMBL8091280

SCHEMBL8091280

CCCCCc1ccccc1.NCCCc1ccccc1

nearest known ligand 0.75

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.72
HTR2A P28223 4/20 0.64
KCNH2 Q12809 1/20 0.58
CYP2A6 P11509 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
TAAR1 Q96RJ0 1/20 0.54
LOXL2 Q9Y4K0 1/20 0.54
SIGMAR1 Q99720 3/20 0.53
MAOB P27338 2/20 0.52
TLR8 Q9NR97 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Phenyl-Butylamine SCHEMBL8343768 0.96 MAOA (0.79) MAOAHTR2AKCNH2CYP2A6SMN1; SMN2
4-Phenyl-Butylamine SCHEMBL9373863 0.96 MAOA (0.79) MAOAHTR2AKCNH2CYP2A6SMN1; SMN2
Butylamine SCHEMBL23671987 0.94 MAOA (0.69) MAOAHTR2AKCNH2CYP2A6SMN1; SMN2
Butylamine SCHEMBL27594153 0.94 MAOA (0.69) MAOAHTR2AKCNH2CYP2A6SMN1; SMN2
Propylamine SCHEMBL8976772 0.94 MAOA (0.68) MAOAHTR2AKCNH2CYP2A6SMN1; SMN2
Propylamine SCHEMBL8977021 0.92 HTR2A (0.70) MAOAHTR2AKCNH2CYP2A6SMN1; SMN2
4-Phenyl-Butylamine SCHEMBL8096620 0.92 MAOA (0.79) MAOAHTR2AKCNH2CYP2A6SMN1; SMN2
Ethylenediamine SCHEMBL28895391 0.92 HTR2A (0.70) MAOAHTR2AKCNH2CYP2A6SMN1; SMN2
Methylamine SCHEMBL6014456 0.89 KCNH2 (0.63) MAOAHTR2AKCNH2SIGMAR1MAOB
SCHEMBL6282191 0.89 HTR2A (0.79) MAOAHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed