Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2023658 | 0.83 | KCNH2 (0.68) | KCNH2NPC1MAPT | |
| SCHEMBL2023657 | 0.83 | KCNH2 (0.68) | KCNH2NPC1MAPT | |
| SCHEMBL12576482 | 0.73 | MAPT (0.68) | KCNH2ADRB2ADRB1ADRB3MAPT | |
| SCHEMBL14864581 | 0.72 | MAPT (0.55) | KCNH2MAPT | |
| SCHEMBL2016782 | 0.67 | KCNH2 (0.68) | KCNH2ADRB2ADRB1ADRB3MAPT | |
| SCHEMBL2016784 | 0.67 | KCNH2 (0.68) | KCNH2ADRB2ADRB1ADRB3MAPT | |
| SCHEMBL2025770 | 0.66 | KCNH2 (0.61) | KCNH2DRD2DRD3MAPT | |
| SCHEMBL2025768 | 0.66 | KCNH2 (0.61) | KCNH2DRD2DRD3MAPT | |
| SCHEMBL12577213 | 0.65 | TSHR (0.53) | KCNH2MAPT | |
| SCHEMBL430722 | 0.65 | DRD2 (0.43) | NPC1HDAC1DRD2DRD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006437-A1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | EMORY UNIVERSITY (US) | 2009-01-08 | — | — | WO | disclosed |