Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6513698 | 0.99 | NISCH (0.97) | NISCHCYP1A2TSHRADRA2AADRA2B | |
| SCHEMBL10764582 | 0.86 | NISCH (0.74) | NISCHCYP1A2TSHRADRA2AADRA2B | |
| SCHEMBL11001474 | 0.84 | NISCH (0.72) | NISCHCYP1A2TSHRADRA2AADRA2B | |
| Isaglidole SCHEMBL114184 | 0.84 | NISCH (0.72) | NISCHCYP1A2TSHRADRA2AADRA2B | |
| Isaglidole SCHEMBL30659750 | 0.84 | NISCH (0.72) | NISCHCYP1A2TSHRADRA2AADRA2B | |
| SCHEMBL6054462 | 0.82 | NISCH (0.69) | NISCHADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL11097073 | 0.81 | NISCH (0.67) | NISCHCYP1A2TSHRADRA2AADRA2B | |
| SCHEMBL11098729 | 0.79 | NISCH (0.65) | NISCHADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL8673343 | 0.76 | CYP1A2 (1.00) | NISCHCYP1A2TSHRADRA2AADRA2B | |
| SCHEMBL29766842 | 0.76 | CYP1A2 (1.00) | NISCHCYP1A2TSHRADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254777-B1 | Use of imidazolinylaminoisoindolines and related compounds for the manufacture of a medicament for the treatment of hyperglycaemia. | BEECHAM GROUP PLC (GB) | 1992-03-04 | — | — | EP | claimed |
| EP-0212783-B1 | USE OF IMIDAZOLINYLAMINOISOINDOLINES AND RELATED COMPOUNDS IN THE TREATMENT OF HYPERGLYCAEMIA | BEECHAM GROUP PLC (GB) | 1992-01-08 | — | — | EP | claimed |
| US-4847280-A | HYPOGLYCEMIC AGENTS | BEECHAM GROUP PLC (GB) | 1989-07-11 | — | — | US | claimed |
| EP-0254777-A2 | Use of imidazolinylaminoisoindolines and related compounds for the manufacture of a medicament for the treatment of hyperglycaemia. | BEECHAM GROUP PLC (GB) | 1988-02-03 | — | — | EP | claimed |
| EP-0226199-A2 | Isoindole derivatives as medicaments | Beiersdorf Aktiengesellschaft (DE) | 1987-06-24 | — | — | EP | claimed |
| EP-0212783-A2 | Use of imidazolinylaminoisoindolines and related compounds in the treatment of hyperglycaemia | BEECHAM GROUP PLC (GB) | 1987-03-04 | — | — | EP | claimed |
| EP-0072954-B1 | ISOINDOLIN-2-YL-AMINO-IMIDAZOLINES AND ISOINDOLIN-2-YL GUANIDINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Beiersdorf Aktiengesellschaft (DE) | 1986-12-30 | — | — | EP | claimed |
| US-4526897-A | Hypertensive agents | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1985-07-02 | — | — | US | claimed |
| EP-0072954-A2 | Isoindolin-2-yl-amino-imidazolines and isoindolin-2-yl guanidines, process for their preparation and their use as medicines | Beiersdorf Aktiengesellschaft (DE) | 1983-03-02 | — | — | EP | claimed |
| US-4221798-A | Hypotensive 2-heterocycloamino-imidazolines | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1980-09-09 | — | — | US | claimed |
| WO-2016105449-A1 | COMPOUNDS FOR USE AS PAIN THERAPEUTICS | LEDERMAN SETH (US) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016105448-A1 | IMIDAZOLINE RECEPTOR TYPE 1 LIGANDS FOR USE AS THERAPEUTICS | RIDEOUT DARRYL (US) | 2016-06-30 | — | — | WO | disclosed |
| US-6162455-A | Method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals | AMERICAN CYANAMID COMPANY (US) | 2000-12-19 | — | — | US | disclosed |
| US-5141933-A | Treatment for hyperglycaemia | BEECHAM GROUP P.L.C. (GB) | 1992-08-25 | — | — | US | disclosed |
| EP-0254777-B1 | Use of imidazolinylaminoisoindolines and related compounds for the manufacture of a medicament for the treatment of hyperglycaemia. | BEECHAM GROUP PLC (GB) | 1992-03-04 | — | — | EP | disclosed |
| EP-0212783-A2 | Use of imidazolinylaminoisoindolines and related compounds in the treatment of hyperglycaemia | BEECHAM GROUP PLC (GB) | 1987-03-04 | — | — | EP | disclosed |
| EP-0072954-B1 | ISOINDOLIN-2-YL-AMINO-IMIDAZOLINES AND ISOINDOLIN-2-YL GUANIDINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Beiersdorf Aktiengesellschaft (DE) | 1986-12-30 | — | — | EP | disclosed |
| US-4526897-A | Hypertensive agents | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1985-07-02 | — | — | US | disclosed |
| EP-0072954-A2 | Isoindolin-2-yl-amino-imidazolines and isoindolin-2-yl guanidines, process for their preparation and their use as medicines | Beiersdorf Aktiengesellschaft (DE) | 1983-03-02 | — | — | EP | disclosed |
| US-4221798-A | Hypotensive 2-heterocycloamino-imidazolines | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1980-09-09 | — | — | US | disclosed |