SCHEMBL8091426

SCHEMBL8091426

Nc1ccccc1Sc1sc(Cl)cc1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.45
PKM P14618 1/20 0.45
PDE7A Q13946 6/20 0.44
MAPT P10636 3/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
NPSR1 Q6W5P4 1/20 0.41
APOBEC3G Q9HC16 1/20 0.41
KDM4E B2RXH2 3/20 0.39
TDP1 Q9NUW8 2/20 0.39
GLA P06280 1/20 0.39
GFER P55789 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
TSHR P16473 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
STAT3 P40763 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8100946 0.73 PDE7A (0.51) ALDH1A1PDE7AMAPTKDM4ETDP1
SCHEMBL8098736 0.71 ALDH1A1 (0.44) ALDH1A1PKMPDE7AMAPTMEN1
SCHEMBL29869345 0.70 MEN1 (0.68) ALDH1A1PKMPDE7AMAPTMEN1
SCHEMBL713707 0.70 MEN1 (0.68) ALDH1A1PKMPDE7AMAPTMEN1
SCHEMBL4096798 0.68 TSHR (0.50) ALDH1A1PKMPDE7AMAPTMEN1
SCHEMBL1341957 0.68 ITGB2 (0.62) ALDH1A1PKMPDE7AMAPTMEN1
Hydrochloric Acid SCHEMBL8645056 0.68 MEN1 (0.65) ALDH1A1PKMPDE7AMAPTMEN1
SCHEMBL6003193 0.68 MEN1 (0.65) ALDH1A1PKMPDE7AMAPTMEN1
SCHEMBL1339081 0.66 PDE7A (0.57) ALDH1A1PKMPDE7AMAPTMEN1
SCHEMBL31016398 0.64 CYP1A2 (0.53) ALDH1A1PKMPDE7AMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0848703-B1 DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II NYCOMED AUSTRIA GMBH (AT) 2000-09-27 EP disclosed
US-6004948-A NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION NYCOMED AUSTRIA GMBH (AT) 1999-12-21 US disclosed
EP-0848703-A1 DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II Nycomed Austria GmbH (AT) 1998-06-24 EP disclosed
WO-1997003953-A1 DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II NYCOMED AUSTRIA GMBH (AT) 1997-02-06 WO disclosed