Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11712943 | 0.81 | CYP19A1 (0.39) | KMT2AMEN1 | |
| SCHEMBL6568512 | 0.80 | ALDH1A1 (0.61) | ALDH1A1LTA4HPBRM1KMT2AMEN1 | |
| SCHEMBL1170712 | 0.80 | CYP19A1 (0.40) | KMT2AMEN1POLB | |
| SCHEMBL24371959 | 0.79 | KMT2A (0.59) | ALDH1A1LTA4HKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9864385 | 0.79 | TAAR1 (0.57) | ALDH1A1KDM4E | |
| SCHEMBL6570932 | 0.78 | CYP19A1 (0.46) | — | |
| SCHEMBL27496419 | 0.77 | TAAR1 (0.55) | ALDH1A1KDM4E | |
| SCHEMBL27829880 | 0.77 | ALDH1A1 (0.57) | ALDH1A1LTA4HKMT2AMEN1TDP1 | |
| SCHEMBL26152583 | 0.77 | ALDH1A1 (0.75) | ALDH1A1LTA4HKMT2AMEN1KDM4E | |
| SCHEMBL7452354 | 0.76 | ALDH1A1 (0.56) | ALDH1A1LTA4HGAAMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124328-A | TREATING NERVE CELLS WITH A NEUROTROPHIC AGENT; PROMOTING REPAIR OF NEURONAL DAMAGE CAUSED BY DISEASE OR PHYSICAL TRAUMA | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-09-26 | — | — | US | disclosed |
| US-6037370-A | TREATING ALZHEIMER*S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, PARKINSON*S DISEASE, AND OTHER NERVOUS SYSTEM DISORDERS WITH PEPTIDE DERIVATIVES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-03-14 | — | — | US | disclosed |