Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 2/20 | 0.39 |
| ▸ | CDC25B | P30305 | 2/20 | 0.39 |
| ▸ | PPM1D | O15297 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091627 | 1.00 | CDC25A (0.39) | CDC25ACDC25BPPM1D | |
| SCHEMBL8503807 | 1.00 | CDC25A (0.39) | CDC25ACDC25BPPM1D | |
| SCHEMBL3175300 | 0.94 | CDC25A (0.45) | CDC25ACDC25BPPM1D | |
| SCHEMBL14107820 | 0.94 | CDC25A (0.45) | CDC25ACDC25BPPM1D | |
| SCHEMBL3175294 | 0.94 | CDC25A (0.45) | CDC25ACDC25BPPM1D | |
| SCHEMBL3175287 | 0.94 | CDC25A (0.45) | CDC25ACDC25BPPM1D | |
| SCHEMBL9010602 | 0.94 | CDC25A (0.45) | CDC25ACDC25BPPM1D | |
| SCHEMBL14444978 | 0.94 | CDC25A (0.45) | CDC25ACDC25BPPM1D | |
| SCHEMBL8083668 | 0.88 | CDC25A (0.39) | CDC25ACDC25BPPM1D | |
| SCHEMBL8098457 | 0.88 | CDC25A (0.39) | CDC25ACDC25BPPM1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043385-A | TREATMENT OF PSORIASIS, BASAL CELL CARCINOMAS, DISORDERS OF KERATINIZATION AND KERATOSIS, NEOPLASTIC DISEASES SUCH AS LEUKEMIA, DISORDERS OF THE SEBACEOUS GLANDS SUCH AS ACNE AND SEBORRHOIC DERMATITIS, OSTEOPOROSIS, HYPERPARATHYROIDISM | HOFFMAN-LA ROCHE INC. (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0771789-B1 | 1 alpha, 26-dihydroxy-D-homo-vitamin D3 | HOFFMANN LA ROCHE (CH) | 2000-02-16 | — | — | EP | disclosed |
| EP-0771789-A1 | 1 alpha, 26-dihydroxy-D-homo-vitamin D3 | F. HOFFMANN-LA ROCHE AG (CH) | 1997-05-07 | — | — | EP | disclosed |