Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 4/20 | 0.45 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
| ▸ | PPM1D | O15297 | 2/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.32 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.31 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175287 | 1.00 | CDC25A (0.45) | CDC25ACDC25BPPM1DGPBAR1AKR1B10 | |
| SCHEMBL3175300 | 1.00 | CDC25A (0.45) | CDC25ACDC25BPPM1DGPBAR1AKR1B10 | |
| SCHEMBL9010602 | 1.00 | CDC25A (0.45) | CDC25ACDC25BPPM1DGPBAR1AKR1B10 | |
| SCHEMBL14444978 | 1.00 | CDC25A (0.45) | CDC25ACDC25BPPM1DGPBAR1AKR1B10 | |
| SCHEMBL14107820 | 1.00 | CDC25A (0.45) | CDC25ACDC25BPPM1DGPBAR1AKR1B10 | |
| SCHEMBL8503807 | 0.94 | CDC25A (0.39) | CDC25ACDC25BPPM1D | |
| SCHEMBL8091627 | 0.94 | CDC25A (0.39) | CDC25ACDC25BPPM1D | |
| SCHEMBL8091626 | 0.94 | CDC25A (0.39) | CDC25ACDC25BPPM1D | |
| SCHEMBL14598213 | 0.91 | CDC25A (0.48) | CDC25ACDC25BGPBAR1AKR1B10AKR1B1 | |
| SCHEMBL21613301 | 0.91 | CDC25A (0.48) | CDC25ACDC25BGPBAR1AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016435-A1 | HYBRID MOLECULES HAVING MIXED VITAMIN D RECEPTOR AGONISM AND HISTONE DEACETYLASE INHIBITORY PROPERTIES | MCGILL UNIVERSITY (CA) | 2010-01-21 | — | — | US | disclosed |
| US-6043385-A | TREATMENT OF PSORIASIS, BASAL CELL CARCINOMAS, DISORDERS OF KERATINIZATION AND KERATOSIS, NEOPLASTIC DISEASES SUCH AS LEUKEMIA, DISORDERS OF THE SEBACEOUS GLANDS SUCH AS ACNE AND SEBORRHOIC DERMATITIS, OSTEOPOROSIS, HYPERPARATHYROIDISM | HOFFMAN-LA ROCHE INC. (US) | 2000-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016435-A1 | HYBRID MOLECULES HAVING MIXED VITAMIN D RECEPTOR AGONISM AND HISTONE DEACETYLASE INHIBITORY PROPERTIES | VDR, HDAC3, HDAC4 | CDC25A 4255/4885CDC25B 4583/4885PPM1D 4081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.