SCHEMBL8091682

SCHEMBL8091682

c1ccc(CCCNCCCC2CCCCC2)cc1

nearest known ligand 0.66

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 8/20 0.66
KCNH2 Q12809 1/20 0.53
EPHX2 P34913 1/20 0.52
KDM1A O60341 1/20 0.51
MAOA P21397 1/20 0.51
MAOB P27338 1/20 0.51
KMT2A Q03164 2/20 0.50
EPHX1 P07099 1/20 0.50
MEN1 O00255 1/20 0.50
RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8092779 0.98 SIGMAR1 (0.64) SIGMAR1KCNH2EPHX2KDM1AMAOA
SCHEMBL8569329 0.88 SIGMAR1 (0.67) SIGMAR1EPHX2EPHX1
SCHEMBL7419921 0.86 SLC18A3 (0.60) SIGMAR1EPHX2KDM1AMAOAMAOB
SCHEMBL9133642 0.86 SLC18A3 (0.60) SIGMAR1EPHX2KDM1AMAOAMAOB
SCHEMBL2440428 0.86 SLC18A3 (0.60) SIGMAR1EPHX2KDM1AMAOAMAOB
SCHEMBL8084177 0.85 SIGMAR1 (0.58) SIGMAR1KCNH2EPHX2KMT2AEPHX1
SCHEMBL31547204 0.85 SIGMAR1 (0.88) SIGMAR1KDM1AMAOAMAOBKMT2A
SCHEMBL6049169 0.84 SIGMAR1 (0.61) SIGMAR1EPHX2KMT2AEPHX1MEN1
SCHEMBL7103234 0.84 SLC18A3 (0.62) SIGMAR1
SCHEMBL5087578 0.83 SIGMAR1 (0.64) SIGMAR1EPHX2KMT2AEPHX1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US claimed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
WO-1991009594-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1991-07-11 WO claimed