Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | VDR | P11473 | 8/20 | 0.47 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091697 | 1.00 | MEN1 (0.48) | MEN1NR1I2PGRKMT2AVDR | |
| SCHEMBL8615193 | 0.87 | VDR (0.47) | NR1I2PGRVDRMAPTSMN1; SMN2 | |
| SCHEMBL25314638 | 0.86 | VDR (0.56) | VDR | |
| SCHEMBL25895008 | 0.86 | VDR (0.56) | VDR | |
| SCHEMBL25314634 | 0.86 | VDR (0.56) | VDR | |
| SCHEMBL8090252 | 0.86 | VDR (0.56) | VDR | |
| SCHEMBL12398139 | 0.85 | VDR (0.53) | VDR | |
| SCHEMBL8090430 | 0.85 | MAPT (0.57) | MEN1NR1I2PGRKMT2AVDR | |
| SCHEMBL8776002 | 0.85 | VDR (0.53) | NR1I2PGRVDRMAPTSMN1; SMN2 | |
| SCHEMBL20461073 | 0.85 | VDR (0.59) | NR1I2PGRVDRSREBF1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043385-A | TREATMENT OF PSORIASIS, BASAL CELL CARCINOMAS, DISORDERS OF KERATINIZATION AND KERATOSIS, NEOPLASTIC DISEASES SUCH AS LEUKEMIA, DISORDERS OF THE SEBACEOUS GLANDS SUCH AS ACNE AND SEBORRHOIC DERMATITIS, OSTEOPOROSIS, HYPERPARATHYROIDISM | HOFFMAN-LA ROCHE INC. (US) | 2000-03-28 | — | — | US | disclosed |
| WO-1999031055-A1 | NOVEL VITAMIN D3 AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-24 | — | — | WO | disclosed |