Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 14/20 | 0.63 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.63 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.60 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.60 |
| ▸ | MMP9 | P14780 | 11/20 | 0.54 |
| ▸ | MMP13 | P45452 | 3/20 | 0.54 |
| ▸ | MMP1 | P03956 | 2/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | MMP8 | P22894 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7654716 | 0.98 | MMP2 (0.61) | MMP2ADAMTS5SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL8839423 | 0.86 | MMP2 (0.64) | MMP2ADAMTS5SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL8839436 | 0.86 | MMP2 (0.64) | MMP2ADAMTS5SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL6500230 | 0.85 | MMP2 (0.61) | MMP2ADAMTS5SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL383079 | 0.85 | MMP2 (0.61) | MMP2ADAMTS5SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL1876081 | 0.85 | MMP2 (0.60) | MMP2ADAMTS5SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL14608753 | 0.84 | MMP2 (0.53) | MMP2ADAMTS5MMP9MMP13MMP1 | |
| SCHEMBL7099492 | 0.84 | MMP2 (0.63) | MMP2ADAMTS5SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4041728 | 0.84 | TDP1 (0.63) | MMP2SLC1A3SLC1A2SLC1A1MMP9 | |
| SCHEMBL7370003 | 0.84 | MMP2 (0.72) | MMP2ADAMTS5SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051625-A1 | ASSESSING RISK FOR INTEGRIN ANTAGONIST/AGONIST MEDIATED DISEASES | Du Pont Pharmaceuticals Company (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999038014-A1 | ASSESSING RISK FOR INTEGRIN ANTAGONIST/AGONIST MEDIATED DISEASES | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-07-29 | — | — | WO | disclosed |