Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 6/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083749 | 0.91 | EPHX2 (0.37) | MAPK1PIK3CAMTOREPHX2PIK3CD | |
| SCHEMBL8097397 | 0.89 | PIK3CA (0.48) | PIK3CAMTORATMPIK3CDPIK3CG | |
| SCHEMBL8089929 | 0.87 | PIK3CA (0.48) | PIK3CAMTORATMPIK3CDPIK3CG | |
| SCHEMBL8083867 | 0.81 | PIK3CA (0.52) | PIK3CAMTORATMPIK3CDPIK3CG | |
| SCHEMBL3927521 | 0.81 | PIK3CA (0.60) | PIK3CAMTORATMPIK3CDPIK3CB | |
| SCHEMBL8090668 | 0.80 | PIK3CA (0.35) | MAPK1PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL8099345 | 0.79 | PIK3CD (0.44) | PIK3CAMTORPIK3CDPIK3CGKDR | |
| SCHEMBL8083676 | 0.79 | PIK3CA (0.46) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8099450 | 0.77 | PIK3CA (0.46) | PIK3CAMTORATMPIK3CDPIK3CB | |
| SCHEMBL8083702 | 0.77 | PIK3CD (0.41) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |