Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083132 | 0.81 | NR1H2 (0.48) | JAK3NR1H2NAMPT | |
| SCHEMBL8090935 | 0.81 | NR1H2 (0.42) | JAK3NR1H2NAMPTDDB1CRBN | |
| SCHEMBL8203269 | 0.80 | NR1H2 (0.37) | JAK3NR1H2NAMPT | |
| SCHEMBL8083216 | 0.80 | NAMPT (0.38) | JAK3NR1H2NAMPTGPR119 | |
| SCHEMBL8200316 | 0.73 | NR1H2 (0.37) | JAK3NR1H2NAMPTGPR119 | |
| SCHEMBL8083678 | 0.73 | NR1H2 (0.40) | JAK3NR1H2NAMPTGPR119USP30 | |
| SCHEMBL8092844 | 0.72 | JAK3 (0.39) | JAK3NR1H2NAMPTGPR119USP30 | |
| SCHEMBL8091226 | 0.72 | NR1H2 (0.38) | JAK3NR1H2NAMPT | |
| SCHEMBL8201202 | 0.71 | NR1H2 (0.38) | JAK3NR1H2NAMPTGPR119USP30 | |
| SCHEMBL30954888 | 0.70 | NR1H2 (0.51) | NR1H2NAMPTJAK1JAK2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6018054-A | INTERMEDIATE COMPOUNDS FOR PREPARING NOVEL QUINOLONE AND NAPHTHYRIDONE DERIVATIVES WHICH ARE SUBSTITUTED IN THE 7-POSITION BY A PARTIALLY HYDROGENATED ISOINDOLINYL RING, USE AS ANTIBACTERIAL AGENTS AND AS FEED ADDITIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |