Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201202 | 0.84 | NR1H2 (0.38) | NR1H2JAK3NAMPTALDH1A1MAPT | |
| SCHEMBL8200872 | 0.82 | NR1H2 (0.37) | NR1H2JAK3NAMPTMEN1ALDH1A1 | |
| SCHEMBL8203269 | 0.80 | NR1H2 (0.37) | NR1H2JAK3NAMPTALDH1A1SSTR4 | |
| SCHEMBL8092844 | 0.79 | JAK3 (0.39) | NR1H2JAK3NAMPTMEN1ALDH1A1 | |
| SCHEMBL8083132 | 0.76 | NR1H2 (0.48) | NR1H2JAK3NAMPTMEN1ALDH1A1 | |
| SCHEMBL8090935 | 0.76 | NR1H2 (0.42) | NR1H2JAK3NAMPTMEN1ALDH1A1 | |
| SCHEMBL8083678 | 0.74 | NR1H2 (0.40) | NR1H2JAK3NAMPTMEN1KMT2A | |
| SCHEMBL8091894 | 0.73 | JAK3 (0.38) | NR1H2JAK3NAMPTGPR119 | |
| SCHEMBL30954888 | 0.72 | NR1H2 (0.51) | NR1H2NAMPTGPR119SMN1; SMN2KDM4E | |
| SCHEMBL8096624 | 0.72 | JAK3 (0.37) | NR1H2JAK3NAMPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682030-B1 | 8-Amino-10(azabicycloalkyl)-pyrido[1,2,3-d,e] [1,3,4] benzoxadiazine derivatives, process for their preparation and antibacterial agents containing them | BAYER AG (DE) | 2000-07-05 | — | — | EP | disclosed |
| EP-0647644-B1 | Antibacterial pyrido 1,2,3-d,e 1,3,4 benzoxacin derivatives | BAYER AG (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0588166-B1 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1996-06-05 | — | — | EP | disclosed |
| EP-0682030-A1 | 8-Amino-10(azabicycloalkyl)-pyrido[1,2,3-d,e] [1,3,4] benzoxadiazine derivatives, process for their preparation and antibacterial agents containing them | BAYER AG (DE) | 1995-11-15 | — | — | EP | disclosed |
| EP-0647644-A1 | Antibacterial pyrido 1,2,3-d,e 1,3,4 benzoxacin derivatives | BAYER AG (DE) | 1995-04-12 | — | — | EP | disclosed |
| EP-0588166-A2 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-03-23 | — | — | EP | disclosed |