Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.41 |
| ▸ | MTOR | P42345 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096016 | 0.91 | PIK3CD (0.43) | PIK3CDPIK3CAMTORRAB9AKDR | |
| SCHEMBL8091068 | 0.90 | PIK3CD (0.42) | PIK3CDPIK3CAMTORKDM4ENPC1 | |
| SCHEMBL8090572 | 0.86 | PIK3CD (0.41) | PIK3CDPIK3CAKDR | |
| SCHEMBL8083631 | 0.86 | PIK3CD (0.41) | PIK3CDPIK3CAMTORKDM4ENPC1 | |
| SCHEMBL8083702 | 0.86 | PIK3CD (0.41) | PIK3CDPIK3CAMTORKDM4ENPC1 | |
| SCHEMBL8099039 | 0.86 | PIK3CD (0.49) | PIK3CDPIK3CAMTORKDM4ENPC1 | |
| SCHEMBL8096026 | 0.85 | POLB (0.40) | PIK3CDPIK3CAMTORKDM4EPIK3CB | |
| SCHEMBL8083986 | 0.85 | CA2 (0.39) | PIK3CDPIK3CAMTORKDM4ENPC1 | |
| SCHEMBL8097652 | 0.85 | PIK3CD (0.38) | PIK3CDPIK3CAMTORKDM4ENPC1 | |
| SCHEMBL8098310 | 0.84 | PIK3CD (0.47) | PIK3CDPIK3CAMTORKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |