Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.73 |
| ▸ | HRH1 | P35367 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19043339 | 1.00 | HRH3 (0.73) | HRH3HRH1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL30417282 | 1.00 | HRH3 (0.73) | HRH3HRH1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL20683714 | 0.94 | HRH3 (0.78) | HRH3HRH1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL8111284 | 0.92 | HRH3 (0.81) | HRH3SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11156977 | 0.87 | HRH3 (0.96) | HRH3SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29356024 | 0.85 | HRH3 (1.00) | HRH3SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29283196 | 0.85 | SIGMAR1 (0.59) | HRH3SIGMAR1 | |
| SCHEMBL7392197 | 0.83 | POLB (0.74) | HRH3 | |
| SCHEMBL7399660 | 0.81 | HRH3 (0.71) | HRH3 | |
| Hydrochloric Acid SCHEMBL7403383 | 0.81 | POLB (0.72) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |