Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.59 |
| ▸ | MMP3 | P08254 | 3/20 | 0.56 |
| ▸ | MMP1 | P03956 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741005 | 0.93 | HDAC1 (0.71) | HDAC1HDAC2HDAC10HDAC6HDAC3 | |
| SCHEMBL13954825 | 0.89 | HDAC1 (0.76) | HDAC1HDAC2HDAC10HDAC6HDAC3 | |
| SCHEMBL15336407 | 0.82 | HDAC1 (0.87) | HDAC1HDAC2HDAC10HDAC6HDAC3 | |
| SCHEMBL19275848 | 0.80 | HDAC1 (0.51) | HDAC1HDAC8 | |
| SCHEMBL12099337 | 0.80 | PPARA (0.56) | — | |
| SCHEMBL7044856 | 0.80 | HDAC1 (0.88) | HDAC1HDAC2HDAC10HDAC6HDAC3 | |
| SCHEMBL6966850 | 0.80 | CYP1A2 (0.68) | HDAC1HDAC2HDAC10HDAC6HDAC3 | |
| SCHEMBL3947498 | 0.80 | MMP1 (0.63) | HDAC1HDAC2HDAC10HDAC6HDAC3 | |
| SCHEMBL188550 | 0.79 | MAPT (0.50) | HDAC8 | |
| SCHEMBL15904267 | 0.79 | HDAC1 (0.61) | HDAC1HDAC2HDAC10HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036016-A1 | CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |