SCHEMBL8092310

SCHEMBL8092310

c1ccc(CCCCNCCCc2ccccc2)cc1

nearest known ligand 0.95

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 10/20 0.95

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8084446 0.98 SIGMAR1 (1.00) SIGMAR1
SCHEMBL8092723 0.98 SIGMAR1 (1.00) SIGMAR1
SCHEMBL8084220 0.98 SIGMAR1 (0.95) SIGMAR1
SCHEMBL9819742 0.95 SIGMAR1 (1.00) SIGMAR1
SCHEMBL9819797 0.95 SIGMAR1 (1.00) SIGMAR1
SCHEMBL9819830 0.95 SIGMAR1 (1.00) SIGMAR1
SCHEMBL9655857 0.95 SIGMAR1 (1.00) SIGMAR1
SCHEMBL9819849 0.95 SIGMAR1 (1.00) SIGMAR1
SCHEMBL8092970 0.95 SIGMAR1 (1.00) SIGMAR1
SCHEMBL4254894 0.95 SIGMAR1 (1.00) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US claimed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
EP-0507863-A4 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF 1993-07-07 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
EP-0507863-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1992-10-14 EP claimed
US-5663148-A ANTIINFLAMMATORY AGENTS OF OLIGOPEPTIDES FOR BACTERICIDES, FUNGICIDES, ANTICARCINOGENIC AGENTS, VIRICIDES OR AUTOIMMUNE DISEASES ABBOTT LABORATORIES (US) 1997-09-02 US disclosed
WO-1994007815-A2 SMALL PEPTIDE ANAPHYLATOXIN RECEPTOR LIGANDS ABBOTT LABORATORIES (US) 1994-04-14 WO disclosed
WO-1994007518-A1 ANAPHYLATOXIN RECEPTOR LIGANDS CONTAINING LIPOPHILIC RESIDUES ABBOTT LABORATORIES (US) 1994-04-14 WO disclosed
EP-0279681-A2 Saturated heterocyclic carboxamide derivatives YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1988-08-24 EP disclosed
US-4395410-A Quaternary ammonium antiarrhythmic drugs ELI LILLY AND COMPANY (US) 1983-07-26 US disclosed
EP-0002604-B1 QUATERNARY AMMONIUM SALTS, AND THEIR FORMULATIONS AND PREPARATION ELI LILLY AND COMPANY (US) 1983-05-04 EP disclosed
US-4289787-A PROLONG ACTION POTENTIAL OF CARDIAC TISSUE ELI LILLY AND COMPANY (US) 1981-09-15 US disclosed
EP-0002604-A1 Quaternary ammonium salts, and their formulations and preparation ELI LILLY AND COMPANY (US) 1979-06-27 EP disclosed