Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CASR | P41180 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27826995 | 0.94 | TDP1 (0.56) | TDP1CASRMEN1KMT2AL3MBTL1 | |
| SCHEMBL6552029 | 0.94 | TDP1 (0.56) | TDP1CASRMEN1KMT2AL3MBTL1 | |
| SCHEMBL22445577 | 0.86 | TDP1 (0.58) | TDP1CASRMEN1KMT2AL3MBTL1 | |
| SCHEMBL12493466 | 0.86 | TDP1 (0.58) | TDP1CASRMEN1KMT2AL3MBTL1 | |
| SCHEMBL9063682 | 0.85 | SMN1; SMN2 (0.61) | CASRMEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL2190054 | 0.85 | SMN1; SMN2 (0.61) | CASRMEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL4345247 | 0.85 | SMN1; SMN2 (0.61) | CASRMEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL4846798 | 0.84 | TDP1 (0.53) | TDP1CASRMEN1KMT2AHTT | |
| SCHEMBL9848485 | 0.84 | TDP1 (0.67) | TDP1CASRMEN1KMT2AL3MBTL1 | |
| SCHEMBL5269605 | 0.84 | BCHE (0.59) | MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | disclosed |