Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1259080 | 0.79 | KDM4E (0.47) | KDM4ECA1CA2MMP1MMP2 | |
| SCHEMBL1259082 | 0.79 | KDM4E (0.63) | KDM4ECA1CA2MMP1MMP2 | |
| SCHEMBL13596324 | 0.79 | KDM4E (0.47) | KDM4ECA1CA2MMP1MMP2 | |
| SCHEMBL6910129 | 0.77 | KDM4E (0.61) | KDM4ECA1CA2MMP1MMP2 | |
| SCHEMBL6915538 | 0.77 | KDM4E (0.61) | KDM4ECA1CA2MMP1MMP2 | |
| SCHEMBL6914424 | 0.77 | KDM4E (0.61) | KDM4ECA1CA2MMP1MMP2 | |
| SCHEMBL6914098 | 0.77 | KDM4E (0.61) | KDM4ECA1CA2MMP1MMP2 | |
| SCHEMBL6915536 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1TPMTMETAP2SMN1; SMN2 | |
| SCHEMBL6908359 | 0.77 | KDM4E (0.61) | KDM4ECA1CA2MMP1MMP2 | |
| SCHEMBL6916673 | 0.77 | KDM4E (0.61) | KDM4ECA1CA2MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708077-B1 | Diamino compounds and methods for preparing them | CHISSO CORP (JP) | 2000-12-27 | — | — | EP | disclosed |
| US-5663440-A | Diamino compounds and methods for preparing them | CHISSO CORPORATION (JP) | 1997-09-02 | — | — | US | disclosed |
| EP-0708077-A1 | Diamino compounds and methods for preparing them | CHISSO CORPORATION (JP) | 1996-04-24 | — | — | EP | disclosed |