Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.55 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.54 |
| ▸ | KDM5A | P29375 | 8/20 | 0.54 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.54 |
| ▸ | KDM5C | P41229 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | GGPS1 | O95749 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL17423696 | 0.89 | S1PR2 (0.61) | S1PR2S1PR1S1PR3S1PR5KDM4C | |
| Bicarbonate SCHEMBL27841131 | 0.89 | S1PR2 (0.61) | S1PR2S1PR1S1PR3S1PR5KDM4C | |
| Bicarbonate SCHEMBL17423695 | 0.89 | S1PR2 (0.61) | S1PR2S1PR1S1PR3S1PR5KDM4C | |
| Acetic Acid SCHEMBL18237030 | 0.86 | S1PR2 (0.59) | S1PR2S1PR1S1PR3S1PR5KDM4C | |
| Acetic Acid SCHEMBL9782786 | 0.86 | S1PR2 (0.59) | S1PR2S1PR1S1PR3S1PR5KDM4C | |
| Acetic Acid SCHEMBL6859754 | 0.86 | S1PR2 (0.59) | S1PR2S1PR1S1PR3S1PR5KDM4C | |
| SCHEMBL15407868 | 0.86 | DNM1 (0.60) | S1PR2S1PR1S1PR3S1PR5KDM4C | |
| SCHEMBL4869710 | 0.86 | DNM1 (0.60) | S1PR2S1PR1S1PR3S1PR5KDM4C | |
| SCHEMBL8625464 | 0.86 | DNM1 (0.60) | S1PR2S1PR1S1PR3S1PR5KDM4C | |
| SCHEMBL516694 | 0.86 | DNM1 (0.60) | S1PR2S1PR1S1PR3S1PR5KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |