Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.49 |
| ▸ | CA2 | P00918 | 6/20 | 0.46 |
| ▸ | CA9 | Q16790 | 6/20 | 0.46 |
| ▸ | CA1 | P00915 | 5/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092719 | 0.88 | MALT1 (0.47) | PTGS2PTGS1CA2CA9CA1 | |
| SCHEMBL8099827 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1CA2CA9CA1 | |
| SCHEMBL8419971 | 0.82 | PTGS2 (0.48) | PTGS2PTGS1CA2CA9CA1 | |
| SCHEMBL8095061 | 0.76 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL8094362 | 0.76 | PTGS2 (0.59) | PTGS2PTGS1CA2CA9CA1 | |
| SCHEMBL8093078 | 0.76 | PTGS2 (0.83) | PTGS2PTGS1CA2CA9CA1 | |
| SCHEMBL8095044 | 0.73 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL8094700 | 0.73 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL8093195 | 0.70 | PTGS2 (0.47) | PTGS2PTGS1CA2CA9CA1 | |
| SCHEMBL8085997 | 0.70 | PTGS2 (0.68) | PTGS2PTGS1CA2CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |