Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.51 |
| ▸ | MTOR | P42345 | 8/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.51 |
| ▸ | ATR | Q13535 | 9/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 9/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 9/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.46 |
| ▸ | ATRIP | Q8WXE1 | 8/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218779 | 0.88 | PIK3CA (0.49) | PIK3CAMTORPIK3CDATRPDCD1 | |
| SCHEMBL11926784 | 0.88 | PIK3CA (0.49) | PIK3CAMTORPIK3CDATRPDCD1 | |
| SCHEMBL3598683 | 0.85 | PIK3CA (0.56) | PIK3CAMTORPIK3CDATRPDCD1 | |
| SCHEMBL3723251 | 0.84 | PDCD1 (0.56) | PIK3CAMTORPIK3CDATRPDCD1 | |
| SCHEMBL3723256 | 0.84 | PDCD1 (0.56) | PIK3CAMTORPIK3CDATRPDCD1 | |
| SCHEMBL8213592 | 0.84 | MTOR (0.54) | PIK3CAMTORPIK3CDATR | |
| SCHEMBL739897 | 0.82 | PIK3CA (0.72) | PIK3CAMTORPIK3CDATRPDCD1 | |
| SCHEMBL8215015 | 0.81 | PIK3CA (0.75) | PIK3CAMTORPIK3CD | |
| SCHEMBL3593430 | 0.81 | PIK3CA (0.63) | PIK3CAMTORPIK3CDATRPDCD1 | |
| SCHEMBL11925340 | 0.81 | PIK3CA (0.49) | PIK3CAMTORPIK3CDATRPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007750-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |