Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 11/20 | 0.65 |
| ▸ | AGTR1 | P30556 | 10/20 | 0.62 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8094963 | 0.89 | AGTR2 (0.68) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL8094791 | 0.89 | AGTR2 (0.65) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL8092904 | 0.86 | AGTR2 (0.62) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL8081240 | 0.86 | AGTR2 (0.73) | AGTR2AGTR1 | |
| SCHEMBL8092794 | 0.85 | AGTR2 (0.61) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL8089261 | 0.84 | AGTR2 (0.68) | AGTR2AGTR1PDE4APDE4BPDE4C | |
| SCHEMBL8089368 | 0.81 | AGTR2 (0.75) | AGTR2AGTR1 | |
| SCHEMBL8089484 | 0.79 | AGTR2 (1.00) | AGTR2AGTR1 | |
| SCHEMBL8080820 | 0.79 | AGTR2 (0.72) | AGTR2AGTR1 | |
| SCHEMBL8094888 | 0.79 | AGTR2 (0.71) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |