Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 17/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 17/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092930 | 0.84 | LTB4R2 (0.49) | AGTR1 | |
| SCHEMBL8088498 | 0.77 | MAPT (0.40) | — | |
| SCHEMBL6844560 | 0.73 | CXCR4 (0.42) | AGTR1AGTR2CXCR4CMKLR1MAPK8 | |
| SCHEMBL8474830 | 0.73 | AGTR1 (0.48) | AGTR1AGTR2 | |
| SCHEMBL9589057 | 0.73 | AGTR1 (0.69) | AGTR1AGTR2CXCR4CMKLR1MAPK8 | |
| SCHEMBL9590866 | 0.73 | AGTR1 (0.71) | AGTR1AGTR2 | |
| SCHEMBL8076371 | 0.73 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9295984 | 0.73 | AGTR1 (0.45) | AGTR1AGTR2CXCR4CMKLR1MAPK8 | |
| SCHEMBL9589717 | 0.73 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL8088507 | 0.73 | JAK2 (0.35) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |