Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095724 | 0.97 | PIK3CA (0.39) | PIK3CAMTORPIK3CDALDH1A1NAMPT | |
| SCHEMBL8082658 | 0.92 | PIK3CD (0.39) | PIK3CAPIK3CDALDH1A1NAMPTPOLB | |
| SCHEMBL8089920 | 0.90 | PIK3CD (0.39) | PIK3CAMTORPIK3CDNAMPTPOLB | |
| SCHEMBL8096233 | 0.88 | PIK3CD (0.40) | PIK3CAPIK3CDALDH1A1NAMPTPOLB | |
| SCHEMBL8098248 | 0.88 | PIK3CD (0.39) | PIK3CAPIK3CDNAMPTPOLB | |
| SCHEMBL8089738 | 0.87 | PIK3CD (0.41) | PIK3CAMTORPIK3CDALDH1A1POLB | |
| SCHEMBL8093619 | 0.87 | PIK3CD (0.41) | PIK3CAMTORPIK3CDALDH1A1POLB | |
| SCHEMBL8100146 | 0.86 | CA1 (0.41) | PIK3CAMTORPIK3CDALDH1A1NAMPT | |
| SCHEMBL8090420 | 0.86 | PIK3CD (0.41) | PIK3CAMTORPIK3CDALDH1A1POLB | |
| SCHEMBL8092462 | 0.85 | PIK3CA (0.38) | PIK3CAMTORPIK3CDALDH1A1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |