SCHEMBL8093478

SCHEMBL8093478

CC(C)(C)c1cc(CSCc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc(C(C)(C)C)c1O.CC(C)CCCCCOC(=O)CSCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 2/20 0.37
VCAM1 P19320 9/20 0.35
ALDH1A1 P00352 2/20 0.34
TSHR P16473 2/20 0.34
MEN1 O00255 1/20 0.34
USP2 O75604 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
MAPT P10636 1/20 0.34
MAPK1 P28482 1/20 0.34
BLM P54132 1/20 0.34
KMT2A Q03164 1/20 0.34
ATM Q13315 1/20 0.34
HIF1A Q16665 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
GAA P10253 4/20 0.34
CNR1 P21554 1/20 0.34
CNR2 P34972 1/20 0.34
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL224342 0.99 HMGCR (0.38) HMGCRVCAM1ALDH1A1TSHRMEN1
SCHEMBL10312311 0.99 HMGCR (0.38) HMGCRVCAM1ALDH1A1TSHRMEN1
SCHEMBL10000632 0.89 HMGCR (0.40) HMGCRVCAM1ALDH1A1TSHRMEN1
SCHEMBL870710 0.86 ESR1 (0.43) KMT2AGAA
SCHEMBL581164 0.86 ESR1 (0.43) KMT2AGAA
SCHEMBL8065687 0.86 ESR1 (0.43) KMT2AGAA
SCHEMBL9474261 0.86 HMGCR (0.40) HMGCRVCAM1ALDH1A1TSHRMEN1
SCHEMBL284267 0.84 CYP19A1 (0.43) HMGCRVCAM1ALDH1A1TSHRMEN1
SCHEMBL284478 0.84 CYP19A1 (0.43) HMGCRVCAM1ALDH1A1TSHRMEN1
SCHEMBL284526 0.84 CYP19A1 (0.43) HMGCRVCAM1ALDH1A1TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136900-A POLYDIHYDROPYRIDINES, HYDROTALCITES, ZEOLITES, DAWSONITES, MAGADIITES OR KENYAITES, DISACCHARIDE ALCOHOLS, STERICALLY HINDERED AMINES, AND AT LEAST ONE ZINC, ALUMINIUM OR LANTHANOID COMPOUND, WITCO VINYL ADDITIVES GMBH (DE) 2000-10-24 US disclosed
US-4996326-A Absorbs uv light, stabilizers CIBA-GEIGY CORPORATION (US) 1991-02-26 US disclosed