Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081962 | 0.93 | HCAR3 (0.39) | HCAR3NAMPTERBB2EGFRLMNA | |
| SCHEMBL8096164 | 0.83 | MAPT (0.36) | ERBB2EGFRTP53KDM4EJAK2 | |
| SCHEMBL3265691 | 0.77 | MAPT (0.44) | TP53KDM4EJAK2MAPTALDH1A1 | |
| SCHEMBL8093530 | 0.75 | SIRT2 (0.50) | ERBB2EGFRLMNATP53SMN1; SMN2 | |
| SCHEMBL2991831 | 0.73 | DYRK1A (0.47) | ERBB2EGFRJAK2JAK1 | |
| SCHEMBL8147977 | 0.73 | SCN9A (0.50) | ERBB2EGFRTP53KDM4EMAPT | |
| SCHEMBL2992809 | 0.73 | AURKA (0.46) | ERBB2EGFR | |
| SCHEMBL8093507 | 0.73 | PARP1 (0.37) | KDM4EADORA3ADORA2A | |
| SCHEMBL8150035 | 0.72 | CSNK2A1 (0.38) | EGFRLMNAGRM2MAPTALDH1A1 | |
| SCHEMBL8524532 | 0.72 | SYK (0.46) | KDM4EHSD17B10MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | claimed |
| US-6153617-A | Irreversible bicyclic inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |