SCHEMBL809388

SCHEMBL809388

O=C(c1ccc(Cl)cc1)c1ccc(Cl)cc1.Oc1ccc(C(c2ccc(O)cc2)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.67
ESR1 P03372 3/20 0.60
ESR2 Q92731 2/20 0.60
MAPT P10636 3/20 0.50
LMNA P02545 2/20 0.50
HTT P42858 2/20 0.50
HPGD P15428 2/20 0.50
PKM P14618 1/20 0.50
SRD5A2 P31213 3/20 0.47
ELANE P08246 1/20 0.44
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
POLB P06746 1/20 0.44
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
PTGS2 P35354 1/20 0.42
CYP1A2 P05177 1/20 0.42
GAA P10253 1/20 0.42
CYP2D6 P10635 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7938023 0.88 ESR1 (0.78) MAPK1ESR1ESR2LMNAHPGD
SCHEMBL8053144 0.85 ESR1 (0.62) MAPK1ESR1ESR2MAPTLMNA
SCHEMBL809694 0.84 HPGD (0.51) MAPK1MAPTLMNAHTTHPGD
Hydroquinone SCHEMBL9777901 0.82 MAPK1 (1.00) MAPK1ESR1ESR2MAPTLMNA
Hydroquinone SCHEMBL10635396 0.82 MAPK1 (1.00) MAPK1ESR1ESR2MAPTLMNA
SCHEMBL9457019 0.82 MAPK1 (1.00) MAPK1ESR1ESR2MAPTLMNA
SCHEMBL333466 0.82 MAPK1 (1.00) MAPK1ESR1ESR2MAPTLMNA
SCHEMBL9777896 0.82 MAPK1 (1.00) MAPK1ESR1ESR2MAPTLMNA
SCHEMBL9777899 0.80 MAPK1 (0.95) MAPK1ESR1ESR2MAPTLMNA
Hydroquinone SCHEMBL9777898 0.80 MAPK1 (0.95) MAPK1ESR1ESR2MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1845122-B1 POLYARYLENE, PROCESS FOR PRODUCING THE SAME, SOLID POLYELECTROLYTE, AND PROTON-CONDUCTIVE FILM JSR CORP (JP) 2011-11-16 EP disclosed
US-7893303-B2 Polyarylene, process for producing the same, solid polyelectrolyte, and proton-conductive film JSR CORPORATION (JP) 2011-02-22 US disclosed
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
US-20080015389-A1 Polyarylene, Process For Producing The Same, Solid Polyelectrolyte, And Proton-Conductive Film JSR CORPORATION (JP) 2008-01-17 US disclosed
EP-1845122-A1 POLYARYLENE, PROCESS FOR PRODUCING THE SAME, SOLID POLYELECTROLYTE, AND PROTON-CONDUCTIVE FILM JSR Corporation (JP) 2007-10-17 EP disclosed
US-20070015025-A1 Membrane electrode assembly for solid polymer electrolyte fuel cell HONDA MOTOR CO., LTD. 2007-01-18 US disclosed
US-6833426-B2 A proton-conductive membrane containing the sulfonic acid group-containing polyarylene (co)polymer JSR CORPORATION (JP) 2004-12-21 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080015389-A1 Polyarylene, Process For Producing The Same, Solid Polyelectrolyte, And Proton-Conductive Film PARG, PUF60, PARN MAPK1 1651/4885ESR1 2267/4885ESR2 2996/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.