SCHEMBL8094327

SCHEMBL8094327

O=[N+]([O-])c1ccc(C=Nc2ccc([N+](=O)[O-])cc2)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.76
CA2 P00918 2/20 0.76
CA9 Q16790 2/20 0.76
PTGS2 P35354 2/20 0.76
CA12 O43570 1/20 0.76
KDM4E B2RXH2 4/20 0.67
ALDH1A1 P00352 4/20 0.67
MAPT P10636 3/20 0.67
GRIN2D O15399 2/20 0.54
GRIN3B O60391 2/20 0.54
GRIN1 Q05586 2/20 0.54
GRIN2A Q12879 2/20 0.54
GRIN2B Q13224 2/20 0.54
GRIN2C Q14957 2/20 0.54
GRIN3A Q8TCU5 2/20 0.54
CTDSP1 Q9GZU7 1/20 0.53
AMY1A P0DUB6 1/20 0.53
APP P05067 1/20 0.52
CA7 P43166 1/20 0.52
NPC1 O15118 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14164182 1.00 CA1 (0.76) CA1CA2CA9PTGS2CA12
SCHEMBL11585488 0.94 PTGS2 (0.69) CA1CA2CA9PTGS2CA12
SCHEMBL11585493 0.94 PTGS2 (0.69) CA1CA2CA9PTGS2CA12
SCHEMBL11585495 0.94 PTGS2 (0.69) CA1CA2CA9PTGS2CA12
SCHEMBL12972526 0.91 PTGS2 (0.70) CA1CA2CA9PTGS2CA12
SCHEMBL9458165 0.91 PTGS2 (0.66) CA1CA2CA9PTGS2CA12
SCHEMBL9357922 0.91 PTGS2 (0.66) CA1CA2CA9PTGS2CA12
SCHEMBL8991377 0.91 PTGS2 (0.66) CA1CA2CA9PTGS2CA12
SCHEMBL12972525 0.91 PTGS2 (0.70) CA1CA2CA9PTGS2CA12
SCHEMBL10045508 0.91 PTGS2 (0.66) CA1CA2CA9PTGS2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6118004-A Cyclobutenedione derivative, manufacturing method thereof and non-linear optical device containing the same FUJI XEROX CO., LTD. (JP) 2000-09-12 US disclosed
EP-0761643-B1 Cyclobutenedione derivative, manufacturing method thereof and non-linear optical device containing the same FUJI XEROX CO LTD (JP) 1999-12-22 EP disclosed
US-5948915-A Cyclobutenedione derivative, manufacturing method thereof and non-linear optical device containing the same FUJI XEROX CO., LTD. (JP) 1999-09-07 US disclosed
US-5872256-A Cyclobutenedione derivative, process for preparing the same, and nonlinear optical element FUJI XEROX CO., LTD. (JP) 1999-02-16 US disclosed
US-5811552-A FOR DURABLE, WEATHER PROOF ELEMENTS HAVING HEAT, CHEMICAL AND RADIATION RESISTANCE FUJI XEROX CO., LTD. (JP) 1998-09-22 US disclosed
US-5726317-A NONLINEAR OPTICAL DEVICE FUJI XEROX CO., LTD. (JP) 1998-03-10 US disclosed
US-5659085-A CHEMICAL AND HEAT RESISTANCE; TRANSPARENCY; STABILITY FUJI XEROX CO., LTD. (JP) 1997-08-19 US disclosed
US-5616802-A HEAT RESISTANCE, CHEMICAL RESISTANCE, WEATHERPROOFING, WORKABILITY, RADIATION TRANSPARENT, RADIATION RESISTANCE, CRYSTALLIZABILITY FUJI XEROX CO., LTD. (JP) 1997-04-01 US disclosed
EP-0761643-A2 Cyclobutenedione derivative, manufacturing method thereof and non-linear optical device containing the same FUJI XEROX CO., LTD. (JP) 1997-03-12 EP disclosed