Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.81 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.81 |
| ▸ | CNR1 | P21554 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093872 | 0.91 | PTGS2 (0.83) | PTGS2PTGS1 | |
| SCHEMBL8093929 | 0.90 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8093063 | 0.89 | PTGS2 (0.80) | PTGS2PTGS1 | |
| SCHEMBL8086463 | 0.86 | PTGS2 (0.70) | PTGS2PTGS1CNR1 | |
| SCHEMBL8086506 | 0.85 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL8094773 | 0.84 | PTGS2 (0.58) | PTGS2PTGS1CNR1 | |
| SCHEMBL8085593 | 0.83 | PTGS2 (0.71) | PTGS2PTGS1CNR1 | |
| SCHEMBL8094776 | 0.83 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL8086507 | 0.82 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL8776857 | 0.82 | PTGS2 (0.70) | PTGS2PTGS1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |