Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440706 | 0.85 | HMOX1 (0.40) | HMOX1ALDH1A1HTTPOLBTDP1 | |
| SCHEMBL8104137 | 0.83 | POLB (0.43) | HMOX1ALDH1A1POLBAPPTDP1 | |
| SCHEMBL8439468 | 0.80 | HTR2A (0.40) | HMOX1ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL8110081 | 0.79 | HDAC3 (0.41) | HDAC3LMNAPOLBTDP1 | |
| SCHEMBL8108430 | 0.79 | HMOX1 (0.40) | HMOX1HPGDHDAC3KDM4EALDH1A1 | |
| SCHEMBL8110094 | 0.77 | MAPT (0.43) | MAPT | |
| SCHEMBL8104121 | 0.77 | MAPT (0.43) | MAPT | |
| SCHEMBL8104145 | 0.77 | HPGD (0.40) | HMOX1HPGDHDAC3KDM4EALDH1A1 | |
| SCHEMBL8439597 | 0.75 | HCRTR1 (0.43) | ALDH1A1LMNAPOLBAPPTDP1 | |
| SCHEMBL8094772 | 0.75 | HMOX1 (0.39) | HMOX1HPGDHDAC3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | claimed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | claimed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | claimed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |