SCHEMBL8094811

SCHEMBL8094811

O=C(O)c1cn(-c2ccc(F)cc2)c2cc(Cl)c(F)cc2c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.63
MEN1 O00255 1/20 0.63
KMT2A Q03164 1/20 0.63
KDM4E B2RXH2 3/20 0.62
ALDH1A1 P00352 2/20 0.62
HPGD P15428 1/20 0.62
HSD17B10 Q99714 1/20 0.62
RORC P51449 4/20 0.49
KCNH2 Q12809 2/20 0.48
PIM1 P11309 3/20 0.47
CAPN1 P07384 1/20 0.46
POLB P06746 1/20 0.43
HSP90AA1 P07900 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31683747 1.00 LMNA (0.63) LMNAMEN1KMT2AKDM4EALDH1A1
SCHEMBL6214246 0.95 LMNA (0.60) LMNAMEN1KMT2AKDM4EALDH1A1
SCHEMBL9443566 0.93 LMNA (0.54) LMNAMEN1KMT2AKDM4EALDH1A1
SCHEMBL9443520 0.91 CAPN1 (0.56) LMNAMEN1KMT2AKDM4EALDH1A1
SCHEMBL9126186 0.91 LMNA (0.53) LMNAMEN1KMT2AKDM4EALDH1A1
SCHEMBL9443626 0.90 LMNA (0.55) LMNAMEN1KMT2AKDM4EALDH1A1
SCHEMBL5868709 0.90 LMNA (0.68) LMNAMEN1KMT2AKDM4EALDH1A1
SCHEMBL10475589 0.89 LMNA (0.51) LMNAMEN1KMT2AKDM4EALDH1A1
SCHEMBL9443476 0.88 CAPN1 (0.55) LMNAMEN1KMT2AKDM4EALDH1A1
SCHEMBL9443486 0.87 LMNA (0.53) LMNAMEN1KMT2AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1063747-C Quinolone- and naphthyridonecarboxylic acid derivatives BAYER AG (DE) 2001-03-28 CN disclosed
EP-0704443-B1 Quinolone and naphthyridone carboxylic acid derivatives BAYER AG (DE) 2000-12-27 EP disclosed
US-6018054-A INTERMEDIATE COMPOUNDS FOR PREPARING NOVEL QUINOLONE AND NAPHTHYRIDONE DERIVATIVES WHICH ARE SUBSTITUTED IN THE 7-POSITION BY A PARTIALLY HYDROGENATED ISOINDOLINYL RING, USE AS ANTIBACTERIAL AGENTS AND AS FEED ADDITIVES BAYER AKTIENGESELLSCHAFT (DE) 2000-01-25 US disclosed
EP-0705828-B1 Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents BAYER AG (DE) 1999-12-01 EP disclosed
US-5990122-A SUBSTITUTED IN THE 7-POSITION BY A TRICYCLIC AMINE RADICAL; REDUCED GENOTOXIC PROPERTIES AND INCREASED ANTIBACTERIAL ACTIVITY BAYER AKTIENGESELLSCHAFT (DE) 1999-11-23 US disclosed
US-5986105-A ENANTIOMORPHS AS BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 1999-11-16 US disclosed
CN-1044118-C 7-isoindolinyl-quinolone derivatives and process for their preparation BAYER AG (DE) 1999-07-14 CN disclosed
CN-1189494-A Substituted isoazalene compound BAYER AG (DE) 1998-08-05 CN disclosed
US-5783708-A HEXAHYDROISOINDOLE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1998-07-21 US disclosed
US-5753669-A BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 1998-05-19 US disclosed
US-4994599-A Antibacterial agents ABBOTT LABORATORIES (US) 1991-02-19 US disclosed
US-4940794-A INTERMEDIATES FOR PREPARING ANTIBACTERIAL QUINOLINE-3-CARBOXYLIC ACIDS CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA/RT. (HU) 1990-07-10 US disclosed
US-4940710-A 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids AMERICAN CYANAMID COMPANY (US) 1990-07-10 US disclosed
EP-0310647-A1 QUINOLINE CARBOXYLIC ACID BORIC ACID ANHYDRIDES AND PROCESS FOR THE PREPARATION THEREOF. CHINOIN GYOGYSZER ES VEGYESZET (HU) 1989-04-12 EP disclosed
EP-0131839-B1 QUINOLINE ANTIBACTERIAL COMPOUNDS ABBOTT LABORATORIES (US) 1989-02-01 EP disclosed
CN-88101941-A Process for preparing quinoline carboxylic acid boric anhydride 1988-10-26 CN disclosed
WO-1988007998-A1 QUINOLINE CARBOXYLIC ACID BORIC ACID ANHYDRIDES AND PROCESS FOR THE PREPARATION THEREOF Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. (HU) 1988-10-20 WO disclosed
US-4730000-A 7-SUBSTITUTED AMINO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS AND ESTERS ABBOTT LABORATORIES (US) 1988-03-08 US disclosed
EP-0230053-A2 7-(Substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids AMERICAN CYANAMID COMPANY (US) 1987-07-29 EP disclosed
EP-0131839-A1 Quinoline antibacterial compounds ABBOTT LABORATORIES (US) 1985-01-23 EP disclosed