Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8094808 | 1.00 | NPC1 (0.49) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL8094805 | 1.00 | NPC1 (0.49) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL8108304 | 0.84 | TRPV1 (0.49) | POLBLMNAGAATSHRKMT2A | |
| SCHEMBL8108310 | 0.84 | TRPV1 (0.49) | POLBLMNAGAATSHRKMT2A | |
| SCHEMBL8108458 | 0.84 | TRPV1 (0.49) | POLBLMNAGAATSHRKMT2A | |
| SCHEMBL8108459 | 0.84 | TRPV1 (0.49) | POLBLMNAGAATSHRKMT2A | |
| SCHEMBL8108306 | 0.84 | TRPV1 (0.49) | POLBLMNAGAATSHRKMT2A | |
| SCHEMBL8108451 | 0.78 | HTT (0.49) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL8108405 | 0.78 | HTT (0.49) | NPC1RAB9AHTTSMN1; SMN2POLB | |
| SCHEMBL8094760 | 0.78 | HTT (0.49) | NPC1RAB9AHTTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | claimed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |