Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108458 | 1.00 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8108310 | 1.00 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8108304 | 1.00 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8108306 | 1.00 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8439341 | 0.90 | TRPV1 (0.47) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8104208 | 0.89 | TRPV1 (0.40) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8094808 | 0.84 | NPC1 (0.49) | KMT2ALMNATSHRPOLBGAA | |
| SCHEMBL8094805 | 0.84 | NPC1 (0.49) | KMT2ALMNATSHRPOLBGAA | |
| SCHEMBL8094816 | 0.84 | NPC1 (0.49) | KMT2ALMNATSHRPOLBGAA | |
| SCHEMBL8104077 | 0.81 | TRPV1 (0.52) | TRPV1HPGDALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | claimed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | claimed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |