Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097703 | 1.00 | KMT2A (0.62) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL11538771 | 0.85 | MAOB (0.60) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL11538775 | 0.85 | MAOB (0.60) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL1123001 | 0.79 | KMT2A (0.71) | KMT2AALDH1A1MEN1KDM4ESMN1; SMN2 | |
| SCHEMBL11538215 | 0.77 | MAOB (0.60) | KMT2AALDH1A1MEN1MAPTSMN1; SMN2 | |
| SCHEMBL11538219 | 0.77 | MAOB (0.60) | KMT2AALDH1A1MEN1MAPTSMN1; SMN2 | |
| SCHEMBL8091307 | 0.76 | ALDH1A1 (0.49) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL8097740 | 0.76 | ALDH1A1 (0.49) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL11342127 | 0.76 | KMT2A (0.49) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL11342126 | 0.76 | KMT2A (0.49) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147115-A | SULFONYLUREIDO-4-HALOBENZENE DERIVATIVES; ANTICARCINOGENIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0467621-B1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | LILLY CO ELI (US) | 1994-06-15 | — | — | EP | disclosed |
| US-5216026-A | Administering to the mammal N-1-butanesulfonamide derivatives and salts | ELI LILLY AND COMPANY (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0467621-A1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |