Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dipyridyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | CCR1 | P32246 | 3/20 | 0.64 |
| ▸ | CCR5 | P51681 | 3/20 | 0.64 |
| ▸ | CCR8 | P51685 | 3/20 | 0.64 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | METAP1 | P53582 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridyl SCHEMBL30506646 | 0.93 | KDM4E (0.67) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6573657 | 0.93 | KDM4E (0.67) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL28763258 | 0.93 | KDM4E (0.67) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL17099262 | 0.93 | KDM4E (0.67) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL8605272 | 0.93 | KDM4E (0.67) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL8809477 | 0.87 | KDM4E (0.58) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL8214178 | 0.85 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6496678 | 0.85 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6300635 | 0.85 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL608685 | 0.85 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043370-A | REACTING AROMATIC AMINE WITH AN AROMATIC HALIDE IN PRESENCE OF COPPER CONTAINING CATALYST IN A REACTION SOLVENT HAVING IONIZATION POTENTIAL OF FROM 8.0 TO 9.0 EV. | SANKIO CHEMICAL CO., LTD. (JP) | 2000-03-28 | — | — | US | disclosed |