Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Dipyridyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.88 |
| ▸ | CCR1 | P32246 | 3/20 | 0.88 |
| ▸ | CCR5 | P51681 | 3/20 | 0.88 |
| ▸ | CCR8 | P51685 | 3/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.88 |
| ▸ | POLB | P06746 | 1/20 | 0.88 |
| ▸ | METAP1 | P53582 | 1/20 | 0.88 |
| ▸ | BLM | P54132 | 1/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.88 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.88 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.88 |
| ▸ | NPC1 | O15118 | 6/20 | 0.70 |
| ▸ | TP53 | P04637 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridyl SCHEMBL8214178 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6496507 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6496678 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL7107765 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL6300635 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL8083419 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL5555244 | 1.00 | KDM4E (0.88) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL8962334 | 0.97 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL11114417 | 0.97 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 | |
| Dipyridyl SCHEMBL5147238 | 0.97 | KDM4E (0.93) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111077208-A | Method for electrocatalytic detection of thymol based on polypyridine ruthenium complex | 蚌埠学院 | 2020-04-28 | — | — | CN | claimed |
| EP-2872876-B1 | OPTO-CHEMICAL SENSOR AND ITS USE | JOANNEUM RES FORSCHUNGSGMBH (AT) | 2020-02-19 | — | — | EP | claimed |
| US-10011587-B2 | Multivalent ligands targeting VEGFR | THE METHODIST HOSPITAL SYSTEM (US) | 2018-07-03 | — | — | US | claimed |
| US-8409869-B2 | Hydrogen sensor, hydrogen detecting system and method | NATIONAL TSING HUA UNIVERSITY (TW) | 2013-04-02 | — | — | US | claimed |
| US-20120040469-A1 | HYDROGEN SENSOR, HYDROGEN DETECTING SYSTEM AND METHOD | NATIONAL TSING HUA UNIVERSITY (TW) | 2012-02-16 | — | — | US | claimed |
| US-20080251393-A1 | Comprising system of electrodes operating inside reaction chamber intended to contain system of reagents in solution, system of electrodes comprising at least one working nanoelectrode series, one counter electrode and one reference electrode; for detection of biological molecules | NANO-SIMS S.R.L. (IT) | 2008-10-16 | — | — | US | claimed |
| EP-1964933-A1 | Electrochemical sensor, kit comprising said sensor and process for the production thereof | Nano-Sims S.r.l. (IT) | 2008-09-03 | — | — | EP | claimed |
| US-7338778-B2 | Luminescent method for determining cell oxygen consumption | BECTON, DICKINSON AND COMPANY (US) | 2008-03-04 | — | — | US | claimed |
| US-6991918-B2 | Methods for improving sensitivity of oxygen biosensors | BECTON DICKINSON AND CO., (US) | 2006-01-31 | — | — | US | claimed |
| US-6967086-B2 | Method for determining the presence or absence of respiring cells on a three-dimensional scaffold | BECTON DICKINSON AND COMPANY (US) | 2005-11-22 | — | — | US | claimed |
| US-20020155424-A1 | Device for monitoring cells | PITNER J BRUCE (US) | 2002-10-24 | — | — | US | claimed |
| US-6432697-B1 | SAMPLING CONTAINERS WITH CLOSURES FOR PURE SAMPLES | BECTON, DICKINSON AND COMPANY | 2002-08-13 | — | — | US | claimed |
| US-6432665-B1 | CONTAINERS FOR SAMPLING, RADIATION, FLUORESCENCE AND DETECTION | BECTON, DICKINSON AND COMPANY | 2002-08-13 | — | — | US | claimed |
| US-6395506-B1 | MONITORING ACTIVITY OF DRUGS ON MAMMALIAN OR INSECT CELLS; PREPARE BROTH, INCUBATE WITH LUMINESECENT COMPOUND AND DRUG, IRRADIATE DETECT VISIBILE ADJUSTMENT IN LUMINESCENT ACTIVITY, COMPARE TO CONTROL, ADJUSTMENT IN ACTIVITY INDICATES TOXICITY | BECTON, DICKINSON AND COMPANY | 2002-05-28 | — | — | US | claimed |
| EP-1165746-A1 | TRANSPARENT SAMPLE CONTAINER | Becton, Dickinson and Company (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2001057179-A1 | TRANSPARENT SAMPLE CONTAINER | BECTON, DICKINSON AND COMPANY (US) | 2001-08-09 | — | — | WO | claimed |
| EP-1021557-A1 | MICROBIAL MONITORING DEVICE | Becton, Dickinson and Company (US) | 2000-07-26 | — | — | EP | claimed |
| WO-1998012348-A1 | MICROBIAL MONITORING DEVICE | BECTON, DICKINSON AND COMPANY (US) | 1998-03-26 | — | — | WO | claimed |
| US-5567598-A | DETECTIING PRESENCE OF RESPIRING MICOORGANISM USING FLUORESCENT SENSOR | BECTON DICKINSON AND COMPANY (US) | 1996-10-22 | — | — | US | claimed |
| EP-0509791-A1 | Microbial monitoring device | Becton, Dickinson and Company (US) | 1992-10-21 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011587-B2 | Multivalent ligands targeting VEGFR | KDR, FLT4, FLT1 | KDM4E 2044/4885LMNA 4586/4885CCR1 590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.