Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.54 |
| ▸ | CNR1 | P21554 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093983 | 0.91 | CNR1 (0.44) | PTGS2PTGS1CNR1KDM4EL3MBTL1 | |
| SCHEMBL8086857 | 0.88 | PTGS2 (0.53) | PTGS2PTGS1CNR1MAPK13MAPK12 | |
| SCHEMBL8086366 | 0.87 | PTGS2 (0.63) | PTGS2PTGS1CNR1L3MBTL1 | |
| SCHEMBL8100740 | 0.87 | PTGS2 (0.58) | PTGS2PTGS1CNR1 | |
| SCHEMBL8098782 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1CNR1MAPK13MAPK12 | |
| SCHEMBL8098785 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1CNR1MAPK13MAPK12 | |
| SCHEMBL8094998 | 0.86 | PTGS2 (0.52) | PTGS2PTGS1CNR1L3MBTL1 | |
| SCHEMBL215205 | 0.86 | PTGS2 (0.53) | PTGS2PTGS1CNR1 | |
| SCHEMBL8092731 | 0.85 | PTGS2 (0.64) | PTGS2PTGS1CNR1MAPK13MAPK12 | |
| SCHEMBL8095103 | 0.85 | CNR1 (0.61) | PTGS2PTGS1CNR1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |