Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | HTR2B | P41595 | 2/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088925 | 1.00 | HTR2A (0.55) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL8088837 | 0.94 | FFAR1 (0.55) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL8088838 | 0.94 | FFAR1 (0.55) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL8095717 | 0.90 | HTR2A (0.58) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL8095719 | 0.90 | HTR2A (0.58) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL8102619 | 0.89 | MTNR1A (0.48) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL9019865 | 0.88 | MTNR1A (0.50) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL8097207 | 0.88 | HTR2A (0.53) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL9019866 | 0.88 | MTNR1A (0.50) | HTR2AHTR2CHTR2BMTNR1AMTNR1B | |
| SCHEMBL8088922 | 0.88 | MTNR1A (0.49) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | claimed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | claimed |
| JP-8333314-A | — | — | None | — | — | JP | disclosed |
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |
| JP-H08333314-A | N-ACYL-2-ARYLCYCLOALKYLMETHYLAMINE DERIVATIVE AS MELATONERGIC | BRISTOL MYERS SQUIBB CO | 1996-12-17 | — | — | JP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |