Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD5 | P21918 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096202 | 1.00 | HTR2C (0.51) | HTR2CHTR2AHTR2BMTNR1BMTNR1A | |
| SCHEMBL8098094 | 0.90 | HTR2C (0.54) | HTR2CHTR2AHTR2BMTNR1BMTNR1A | |
| SCHEMBL8098093 | 0.90 | HTR2C (0.54) | HTR2CHTR2AHTR2BMTNR1BMTNR1A | |
| SCHEMBL8098501 | 0.86 | MTNR1B (0.52) | HTR2CHTR2AHTR2BMTNR1BMTNR1A | |
| SCHEMBL8095379 | 0.86 | MTNR1B (0.52) | HTR2CHTR2AHTR2BMTNR1BMTNR1A | |
| SCHEMBL8098503 | 0.86 | MTNR1B (0.52) | HTR2CHTR2AHTR2BMTNR1BMTNR1A | |
| SCHEMBL8095382 | 0.86 | MTNR1B (0.52) | HTR2CHTR2AHTR2BMTNR1BMTNR1A | |
| SCHEMBL8098235 | 0.85 | MTNR1B (0.54) | MTNR1BMTNR1ASLC6A2SLC6A4 | |
| SCHEMBL8098179 | 0.85 | MTNR1B (0.51) | HTR2CHTR2AHTR2BMTNR1BMTNR1A | |
| SCHEMBL8088845 | 0.85 | MTNR1B (0.51) | HTR2CHTR2AHTR2BMTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | claimed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | claimed |
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |