Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546802 | 0.84 | TAAR1 (0.52) | SIGMAR1 | |
| SCHEMBL7369457 | 0.82 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL8091327 | 0.82 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9819797 | 0.82 | SIGMAR1 (1.00) | SIGMAR1CHRM2 | |
| SCHEMBL21243271 | 0.82 | CHRM2 (0.59) | CHRM2 | |
| SCHEMBL9819830 | 0.82 | SIGMAR1 (1.00) | SIGMAR1CHRM2 | |
| SCHEMBL9819849 | 0.82 | SIGMAR1 (1.00) | SIGMAR1CHRM2 | |
| SCHEMBL9819742 | 0.82 | SIGMAR1 (1.00) | SIGMAR1CHRM2 | |
| SCHEMBL9655857 | 0.82 | SIGMAR1 (1.00) | SIGMAR1CHRM2 | |
| SCHEMBL8092970 | 0.82 | SIGMAR1 (1.00) | SIGMAR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |