Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150896 | 0.88 | SIGMAR1 (0.62) | SIGMAR1MEN1KMT2A | |
| SCHEMBL9373855 | 0.87 | SIGMAR1 (1.00) | SIGMAR1MEN1KMT2AL3MBTL1 | |
| SCHEMBL22431534 | 0.86 | SIGMAR1 (0.70) | SIGMAR1 | |
| SCHEMBL8976808 | 0.82 | SIGMAR1 (0.65) | SIGMAR1MEN1KMT2A | |
| SCHEMBL8091277 | 0.82 | SIGMAR1 (0.91) | SIGMAR1MEN1KMT2A | |
| SCHEMBL8099627 | 0.79 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL22558398 | 0.78 | SLC6A4 (0.62) | SIGMAR1 | |
| SCHEMBL19334491 | 0.78 | SIGMAR1 (0.58) | SIGMAR1L3MBTL1 | |
| SCHEMBL19505653 | 0.78 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL19505477 | 0.78 | SIGMAR1 (1.00) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |