Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | SCN1A | P35498 | 4/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.36 |
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091662 | 0.85 | HRH1 (0.47) | DRD4SCN1ASCN8AARKMT2A | |
| SCHEMBL8095680 | 0.84 | PDE4B (0.46) | SCN1ASCN8AACHEOPRK1PHGDH | |
| SCHEMBL13945410 | 0.79 | MEN1 (0.39) | DRD4ARMEN1KMT2A | |
| SCHEMBL5526683 | 0.79 | SCN1A (0.50) | SCN1ASCN8A | |
| SCHEMBL8088026 | 0.79 | HTR2C (0.40) | SCN1ASCN8AARACHEPDE4B | |
| SCHEMBL8095861 | 0.79 | KCNH2 (0.41) | SCN1ASCN8AAR | |
| SCHEMBL8102223 | 0.79 | LMNA (0.40) | DRD4MEN1KMT2A | |
| SCHEMBL13968360 | 0.79 | OPRL1 (0.42) | DRD4AROPRL1MEN1KMT2A | |
| SCHEMBL8094095 | 0.79 | GRIN1 (0.40) | SCN1ASCN8AARPHGDHMEN1 | |
| SCHEMBL8093682 | 0.77 | SCN5A (0.40) | SCN1ASCN8AARMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000085-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES USEFUL AS MODULATORS OF GATED ION CHANNELS | PAINCEPTOR PHARMA CORPORATION (CA) | 2008-12-31 | — | — | WO | disclosed |