SCHEMBL8097167

SCHEMBL8097167

CCCc1cccc2sc(Cl)nc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.56
KMT2A Q03164 4/20 0.39
MEN1 O00255 3/20 0.39
LMNA P02545 2/20 0.38
PDE10A Q9Y233 1/20 0.38
IDO1 P14902 1/20 0.37
GAA P10253 2/20 0.36
MAPT P10636 3/20 0.35
PKM P14618 2/20 0.35
MAPK1 P28482 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
HPGD P15428 1/20 0.35
PSMB8 P28062 1/20 0.35
HTT P42858 1/20 0.35
ELANE P08246 1/20 0.34
KDM4E B2RXH2 1/20 0.33
GRM5 P41594 1/20 0.33
HTR1A P08908 1/20 0.32
DRD2 P14416 1/20 0.32
HTR2A P28223 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7469260 0.86 ALDH1A1 (0.59) ALDH1A1KMT2AMEN1LMNAPDE10A
SCHEMBL9722755 0.80 ALDH1A1 (0.57) ALDH1A1KMT2AMEN1LMNAPDE10A
Iodide SCHEMBL28303360 0.80 MEN1 (0.39) ALDH1A1KMT2AMEN1LMNAIDO1
SCHEMBL11443106 0.80 MEN1 (0.42) ALDH1A1KMT2AMEN1IDO1GAA
SCHEMBL6697206 0.80 MEN1 (0.39) ALDH1A1KMT2AMEN1IDO1GAA
SCHEMBL6694867 0.79 ALDH1A1 (0.43) ALDH1A1KMT2AMEN1IDO1MAPT
SCHEMBL28360022 0.78 TLR8 (0.43) ALDH1A1KMT2AMEN1IDO1GAA
Formamide SCHEMBL5255988 0.74 TLR8 (0.41) ALDH1A1KMT2AMEN1IDO1GAA
SCHEMBL14127131 0.73 ALDH1A1 (0.61) ALDH1A1KMT2AMEN1LMNAPDE10A
SCHEMBL1747925 0.73 ALDH1A1 (0.61) ALDH1A1KMT2AMEN1LMNAPDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6150375-A INHIBITORS OF BOTH OF THE HUMAN 5AR ISOZYMES; BENIGN PROSTATE HYPERPLASIA, MALE PATTERN BALDNESS, ACNE VULGARIS, SEBORRHEA, ANDROGENIC ALOPECIA, HIRSUTISM AND PROSTATE CANCER; BLOCKS THE CONVERSION OF TESTOSTERONE TO 5-ALPHA-DIHYDROTESTOSTERONE ELI LILLY AND COMPANY (US) 2000-11-21 US disclosed
US-5670514-A BENZOQUINOLIN-3-ONE ELI LILLY AND COMPANY (US) 1997-09-23 US disclosed
US-5635197-A BENZO(F)QUINOLIN-3-ONES; ANTICARCINOGENIC AGENTS; BONE DISORDERS ELI LILLY AND COMPANY (US) 1997-06-03 US disclosed
US-5629007-A USING BENZOQUINOLIN-3-ONE DERIVATIVES ELI LILLY AND COMPANY (US) 1997-05-13 US disclosed
US-5622961-A PROSTATE CANCER, SKIN DISORDERS, BALDNESS ELI LILLY AND COMPANY (US) 1997-04-22 US disclosed
US-5622962-A PROSTATE CANCER, SKIN DISORDERS, BALDNESS ELI LILLY AND COMPANY (US) 1997-04-22 US disclosed
US-5578724-A INHIBITORS OF 5-ALPHA-REDUCTASE ELI LILLY AND COMPANY (US) 1996-11-26 US disclosed
WO-1996035422-A1 METHODS FOR INHIBITING BONE LOSS ELI LILLY AND COMPANY (US) 1996-11-14 WO disclosed
EP-0742010-A2 Benzoquinolin-3-ones to inhibit bone loss ELI LILLY AND COMPANY (US) 1996-11-13 EP disclosed
EP-0733365-A2 Use of benzoquinolin-3-ones for the treatment and prevention of prostatic cancer ELI LILLY AND COMPANY (US) 1996-09-25 EP disclosed
US-5550134-A ADMINISTERING TO A MAMMAL FROM A SERIES OF BENZOQUINOLIN-3-ONE COMPOUNDS ELI LILLY AND COMPANY (US) 1996-08-27 US disclosed