Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.37 |
| ▸ | ATR | Q13535 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098188 | 0.90 | CA12 (0.44) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8097581 | 0.88 | MAPT (0.38) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8091937 | 0.88 | CA12 (0.39) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8097252 | 0.87 | CA12 (0.43) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8091781 | 0.87 | CA12 (0.43) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8084383 | 0.86 | PIK3CD (0.38) | PIK3CDCA1CA2PIK3CAATR | |
| SCHEMBL8089229 | 0.86 | PIK3CD (0.38) | PIK3CDCA1CA2PIK3CAATR | |
| SCHEMBL8089094 | 0.86 | PIK3CD (0.43) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8082578 | 0.86 | PIK3CD (0.43) | PIK3CDCA12CA1CA2CA9 | |
| SCHEMBL8097227 | 0.86 | PIK3CD (0.43) | PIK3CDPIK3CAATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |