Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 5/20 | 0.33 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084383 | 1.00 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8097177 | 0.86 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8096724 | 0.84 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8097252 | 0.83 | CA12 (0.43) | PIK3CDPIK3CAMTORCA1CA2 | |
| SCHEMBL8091937 | 0.82 | CA12 (0.39) | PIK3CDPIK3CAMTORCA1CA2 | |
| SCHEMBL8091781 | 0.81 | CA12 (0.43) | PIK3CDPIK3CAMTORCA1CA2 | |
| SCHEMBL8103635 | 0.81 | ATR (0.39) | PIK3CDPIK3CAMTORATRMAPT | |
| SCHEMBL3937118 | 0.80 | PIK3CA (0.63) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3928559 | 0.80 | PIK3CA (0.63) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8098188 | 0.80 | CA12 (0.44) | PIK3CDPIK3CAMTORCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |