Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31329285 | 0.96 | HPGD (0.66) | SMN1; SMN2HPGDFKBP1AALDH1A1KMT2A | |
| SCHEMBL31329313 | 0.96 | HPGD (0.66) | SMN1; SMN2HPGDFKBP1AALDH1A1KMT2A | |
| SCHEMBL31329280 | 0.94 | FKBP1A (0.64) | SMN1; SMN2HPGDFKBP1AALDH1A1KMT2A | |
| SCHEMBL31329327 | 0.92 | FKBP1A (0.64) | SMN1; SMN2HPGDFKBP1AALDH1A1KMT2A | |
| SCHEMBL10305162 | 0.88 | FKBP1A (0.76) | SMN1; SMN2HPGDFKBP1AALDH1A1KMT2A | |
| SCHEMBL9557029 | 0.84 | FKBP1A (0.56) | SMN1; SMN2FKBP1AALDH1A1KMT2ATSHR | |
| SCHEMBL8093089 | 0.84 | HDAC1 (0.58) | SMN1; SMN2HPGDTRPV1SIGMAR1RAB9A | |
| SCHEMBL2833214 | 0.82 | KMT2A (0.69) | SMN1; SMN2HPGDFKBP1AALDH1A1KMT2A | |
| SCHEMBL13068565 | 0.82 | FKBP1A (0.60) | SMN1; SMN2HPGDFKBP1AALDH1A1KMT2A | |
| SCHEMBL9556632 | 0.82 | FKBP1A (0.60) | SMN1; SMN2HPGDFKBP1AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |