Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MVD | P53602 | 2/20 | 0.57 |
| ▸ | ACE | P12821 | 10/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PEPD | P12955 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786825 | 1.00 | MVD (0.57) | MVDACEACE2RAB9AREN | |
| SCHEMBL4867627 | 0.81 | MVD (0.58) | MVDACEACE2RAB9AREN | |
| SCHEMBL2607303 | 0.81 | MVD (0.58) | MVDACEACE2RAB9AREN | |
| SCHEMBL31694871 | 0.81 | MVD (0.58) | MVDACEACE2RAB9AREN | |
| SCHEMBL7710658 | 0.79 | DPP4 (0.45) | MVDACE | |
| SCHEMBL6782701 | 0.78 | ACE (0.72) | MVDACEREN | |
| SCHEMBL6782705 | 0.78 | ACE (0.72) | MVDACEREN | |
| SCHEMBL5742919 | 0.78 | ACE (0.61) | MVDACEACE2LTA4HALDH1A1 | |
| SCHEMBL5742925 | 0.78 | ACE (0.61) | MVDACEACE2LTA4HALDH1A1 | |
| SCHEMBL1537428 | 0.77 | ACE (0.64) | MVDACEACE2RAB9AREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103910-A | FOR TREATMENT OF DISEASES ASSOCIATED WITH AMYLOIDOSIS, SUCH AS ALZHEIMER'S DISEASE, DIABETES MELLITUS, FAMILIAL AMYLOID POLYNEUROPATHY, SCRAPIE, AND KREUZFELD-JACOB DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2000-08-15 | — | — | US | disclosed |