Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TMPRSS4 | Q9NRS4 | 4/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30796116 | 0.90 | KCNQ3 (0.54) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL5857386 | 0.90 | KCNQ3 (0.54) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL8103809 | 0.83 | KCNQ3 (0.64) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL5858074 | 0.83 | KMT2A (0.48) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL5981745 | 0.81 | KMT2A (0.46) | IDO1KMT2AMEN1CYP3A4CYP2C19 | |
| SCHEMBL5857467 | 0.80 | KCNQ3 (0.41) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL7072568 | 0.78 | KCNQ3 (0.69) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL18019010 | 0.78 | KCNQ3 (0.69) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL5858767 | 0.78 | KMT2A (0.43) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL5677990 | 0.77 | IDO1 (0.45) | IDO1KMT2AMEN1BRD4CBX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1076348-C | 3-ketoindole derivates taken as potassium channels regulator | BRISTOL MYERS SQUIBB CO LTD (US) | 2001-12-19 | — | — | CN | disclosed |
| EP-0747354-B1 | 3-Substituted oxindole derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2000-08-16 | — | — | EP | disclosed |
| CN-1144800-A | 3-ketoindole derivates taken as potassium channels regulator | BRISTOL MYERS SQUIBB CO (US) | 1997-03-12 | — | — | CN | disclosed |
| US-5602169-A | USEFUL IN REDUCING NEURONAL DAMAGE DURING ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-02-11 | — | — | US | disclosed |
| US-5565483-A | ADMINISTERING AS THERAPY FOR ISCHEMIA, CONVULSIONS OR ASTHMA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-15 | — | — | US | disclosed |